VLADIMER MIKELASHVILI

Academic Doctor of Science

Vladimer Chavchanidze Institute of Cybernetics of the Georgian Technical University

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Stable aqueous dispersions of bare and double layer functionalized superparamagnetic iron oxide nanoparticles for biomedical applicationsMarkhulia Jano, Kekutia Shalva, Mikelashvili Vladimer, Almásy László, Saneblidze Liana, Tsertsvadze Tamar, Maisuradze Nino, Leladze Nino and Kriechbaum ManfredarticleMaterials Science-Poland, 2021, vol.39, no.3, pp.331-345IF (2020) 1.022 5-year IF: 1.32 CiteScore 2020: 1.8 SCImago Journal Rank (SJR) 2020: 0.257 ISSN: 2083-1331, E-ISSN: 2083-134X DOI: https://doi.org/10.2478/msp-2021-0028EnglishGrant Project
Folic acid conjugation of magnetite nanoparticles using pulsed electrohydraulic dischargesMikelashvili V, Kekutia Sh, Markhulia J, Saneblidze L, Jabua Z, Almásy L, Kriechbaum M.articleJ. Serb. Chem. Soc., 2021, v 86 (2) 181–194IF (2021-2022) 1.24 ISSN: 0352-5139, E-ISSN: 1820-7421 https://doi.org/10.2298/JSC200414053MEnglishState Targeted Program
Synthesis ad properties of RGO-Fe3O4 Hybrid nanomaterial and its polimer CompositeKukhta, A., Jalagonia, N., Kuchukhidze, T., Archuadze, T., Sanaia, E., Bokuchava, G., Mikelashvili, V.articleInterational Journal of Nanoscience, 2019, Vol 18, Nos. 3&4 1940076 (4 pages)SJR 2020 0.197 ISSN (print): 0219-581X ; ISSN (online): 1793-5350 https://doi.org/10.1142/S0219581X19400763EnglishGrant Project
Synthesis and in vivo investigation of therapeutic effect of magnetite nanofluids in mouse prostate cancer modelMarkhulia J., Kekutia S., Mitskevich N., Mikelashvili V., Saneblidze L., Leladze N., Jabua Z., Sacarescu L., Kriechbaum M., Almásy L. articleDigest Journal of Nanomaterials and Biostructures, 2018, Vol.13, No.4, p. 1081-1090Impact IF 0.963, SJR 2020 0.256 ISSN: 1842-3582  http://www.chalcogen.ro/1081_MarkhuliaJ.pdfEnglishGrant Project
The Synthesis of PEG-Modified Superparamagnetic Iron Oxide Nanoparticles (SPIONs) and the Study of their Bactericidal Effects on Staphylococcus epidermidis.Sh.Kekutia, L.Saneblidze, V.Sokhadze, M.Abuladze, E.Namchevadze, L.Tabatadze, G.Tvauri, V.Mikelashvili, J.Markhulia.articleსაქართველოს მეცნიერებათა ეროვნული აკადემიის მაცნე, ქიმიის სერია, 2017, ტ. 43, №2, გვ 247-254 ISSN – 0132 – 6074 https://dspace.nplg.gov.ge/handle/1234/188210?offset=0EnglishState Targeted Program
Chemical co-precipitation synthesis and characterization of polyethylene glycol coated iron oxide nanoparticles for biomedical applicationsMarkhulia, J., Kekutia, S., Jabua, Z., Mikelashvili, V., Saneblidze, L.conference proceedingsSGEM2017 (SGEM Scientific eLibrary), Nano, Bio and Green Technologies for a Sustainable Future, 2017, Vol. 17, Issue 61, 51-58 pp.Impact IF 0.29 (2017) ISBN: 978-619-7408-12-6; ISSN: 1314-2704 DOI:10.5593/sgem2017/61/S24.007EnglishGrant Project
Applicationof Pulsed Arc Electrohydraulic Discharges for the Synthesis of PVA and Dextran coated Magnetic nanoparticlesMikelashvili V, Kekutia S, Markhulia J, Saneblidze L. articleGlob J Nano. 2017; 3(3): 555613.Impact IF 0.649 (2019-20) ISSN: 2573-2374  DOI: 10.19080/GJN.2017.03.555613.EnglishGrant Project
Some Physical Parameters of PEG- modified Magnetite NanofluidsJ. Markhulia, V. Mikelashvili, Sh. Kekutia, L. Saneblidze, Z. Jabua, D. Daraselia, D.Jafaridze articleJournal of Pharmaceutical and Applied Chemistry, 2, No. 2, 33-37 (2016) Online ISSN 2357-0210 DOI: 10.21608/jpac.2016.202793EnglishGrant Project
Solar cells based on InP/GaP/Si structureO. Kvitsiani ; D. Laperashvili ; T. Laperashvili, V. Mikelashviliconference proceedingsProc. SPIE 10019, Optoelectronic Devices and Integration VI, 100191G (2016)SJR 2020 0.192 ISSN:0277-786XE-ISSN:1996-756X http://dx.doi.org/10.1117/12.2248086EnglishState Targeted Program
New Method of Preparation of Superparamagnetic Nanoparticles Sh. Kekutia, L. Saneblidze, V. Mikelashvili, J. Markhulia, R. Tatarashvili, D. Daraselia, D. Japaridze. articleEuropean Chemical Bulletin, 2015, 4(1), 33-36,  SJR: 0.131 ISSN 2063-5346 DOI: 10.17628/ECB.2015.4.33EnglishGrant Project
The Effect of Electrohydraulic Discharge for High Dispersive Magnetic Nanofluid V.Mikelashvili, J. Markhulia, Sh. Kekutia, R. TatarashviliarticleNano Studies, 2014, 9, 87-92. ISBN 978-9941-28-320-8 https://dspace.nplg.gov.ge/handle/1234/140697EnglishGrant Project
Use of electro-hydraulic effect to obtain high-dispersion magnetic nanofluid for medical purposesMikelashvili V., Markhulia J., Kekutia Sh., Tatarashvili R,conference proceedings2nd International Conference "Nanotechnologies" Nano - 2012, Scientific. Conf. Works, (2012), p. 30-37, ISBN: 978-9941-436-47-5 https://dspace.nplg.gov.ge/handle/1234/141858GeorgianState Targeted Program
Synthesis of magnetic nanofluid and perspectives of its use in medicineSh. Kekutia., V. Mikelashvili, J. Markhulia, L. Saneblidze, Sh. Akhobadze.conference proceedingsInternational scientific Conference Proceedings (Physical Methods of Research in Medicine). 2012, p. 30-37 ISBN 978-9941-436-47-5 GeorgianState Targeted Program
Structural disorders in GaMnSb films and their impact on the anomalous Hall effectv.Mikelashviliconference proceedingsPhotonics, Science. Conf. materials. 2011 Stu, pp.70-77 ISBN 978-9941-14-933-7 GeorgianGrant Project
Obtaining and Investigating Low-Resistance ohmic Contacts on Gallium Arsenide "T. Laperashvili, O. Kvitsiani, I. Glonti, T. Guliashvili, V. Mikelashvili,conference proceedingsPhotonics, Science. Conf. materials. 2011, GTU 121-130 p. ISBN 978-9941-14-933-7 GeorgianState Targeted Program
Synthesis of magnetic nanofluids for medical appointmentSh. Kekutia, V. Mikelashvili, J. markhulia, l. Saneblidze, M. Chavchanidze,conference proceedingsPhotonics, Science. Conf. materials. 2011 GTU, 194-205 p. ISBN 978-9941-14-933-7 GeorgianState Targeted Program
Fabrication of nanostructures with quantum dots on III–V semiconductors by coating and heat treatment of Group III metalsLaperashvili T., Markhulia J., Kvitsiani O., Imerlishvili I., Laperashvili D., Mikelashvili V.,conference proceedingsJournal of Nanochemistry - Nanotechnologies, (2010) 193-198 p ISBN: 978-9941-416-34-7 GeorgianState Targeted Program
Electrical characteristics of Fe/GaAs structuresMikelashvili V.T., Kvitciani O, R., Laperashvili D.L., Laperarshvili T.A. articleGEN 2008, 4, pp.23-26, ISSN 1512- 0287 EnglishState Targeted Program
Nanostructure – Based Spinelectronics Sensory MaterialsKervalishvili P.J., Gogua Z., Mikelashvili V.T, articleNovel Materials, Annual Collection of Selected Papers, Georgian Engineering News, 2006, pp.7-14. EnglishState Targeted Program
Properties of Boron Carbide Films Prepared by a Lazer Plazma Deposition MethodShalamberidze S. O., Kervalishvili P. J, Mikelashvili V. T, articleGEN, 2004,3, pp.16-21, ISSN 1512-0287 https://gen.techinformi.ge/inf23.htmEnglishState Targeted Program

IV International Baltic Conference on Magnetism, (29 Aug – 2 sept), 2021 Svetlogorsk, Kaliningrad region, RussiaSvetlogorsk, Kaliningrad region, Russia202129 Aug – 2 septIBCM-2021Synthesis and characterization Citric acid-modified Iron oxide nanoparticles for biomedical applicationposter

The most conventional method for obtaining Fe3O4 or γ-Fe2O3 is chemical co-precipitation. In our work we propose a simple and cost-effective method for obtaining colloidal suspensions composed of Fe3O4 nanoparticles coated with CA and dispersed in a liquid carrier (distilled water). Our particles were synthesized by chemical co-precipitation with ultrasonication (sonolysis) in a low vacuum environment [1,2]. Before coating with CA, the obtained IONPs were processed by electrohydraulic discharges in the high discharge current (HC) (several tens of Amperes) and low discharge current (LC) (several Amperes) modes in water medium using pulsed direct current (PDC). X-ray Powder Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS), Ultraviolet-Visible Spectroscopy (UV VIS), and Small Angle X-Ray Scattering (SAXS) were used to characterize the obtained samples.

https://www.mdpi.com/journal/nanomaterials/events/13223
Nanotech France 2021 The 6th ed. of Nanotech France 2021 Int. Conference and ExhibitionParis, France202123-25 JuneSetcor Conference and ExhibitionEvaluation of doxorubicin-loaded magnetite nanoparticles Synthesis and in vitro cytotoxicity on 4T1 tumorigenic epithelial cell linesoral

Breast cancer is the most commonly diagnosed tumor formation in women around the world, which is also the leading cause of female cancer mortality. Although significant progress has been made in the diagnosis and therapy of breast cancer, early detection of disease and antimetastatic treatment still remain a serious problem. The development of the next generation of cancer therapy modalities is relevant in modern oncology. Nanotechnology offers promising prospects in this direction. Recently, the uptake of multifunctional iron oxide nanoparticles, combining both therapeutic and diagnostic capabilities, is gaining increasing attention in terms of cancer treatment, diagnosis, and targeted drug delivery. This study is dedicated to the synthesis of Citric acid-modified Superparamagnetic Iron Oxide Nanoparticles (SPIONs) functionalized with an anti-cancer drug Doxorubicin (DOX), using a controlled chemical co-precipitation method and study in vitro cytotoxicity of obtained magnetic nanofluids (containing Bare, Citric acid-coated, and DOX-loaded IONPs) on 4T1 tumorigenic epithelial cell lines (Figure 1). The synthesized samples were characterized using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Small-Angle X-ray Scattering (SAXS), Vibrating Sample Magnetometry (VSM), and UV-VIS spectrophotometry. To properly analyze and understand the behavior of 4T1 cancer cells after administrating Bare, Citric acid modified, and DOX-loaded IONPs in comparison with free DOX, a complex set of in vitro tests were used, including MTT assay, determination of the cell cycle, and IONPs uptake. Synthesized magnetic nanofluids containing Iron ox-ide nanoparticles (both Bare and modified with citric acid), revealed cytotoxicity on 4T1 cancer cells. However, the results showed the advantage of a combination of doxorubicin and magnetic nanoparticles. The DOX-loaded IONPs were more able to inhibit the growth and proliferation of 4T1 breast cancer cells in vitro, indicating that the system has the potential to act as an antitumor chemotherapeutic agent.

https://www.setcor.org/conferences/nanotech-france-2021
2019 IEEE 9th International Conference on “Nanomaterials: Applications & Properties”Odesa, Ukraine201915-20 SeptemberNAP-2019 The Effect of Pulsed Arc Electrohydraulic Discharges on the Modification of Magnetite Nanoparticles with Bioactive Molecule – Folic Acidposter

Among the broad range of nanoscale materials such as Fe3O4, γ-Fe2O3, CоFe2O4, ZnFe2O4, BaFe12O19 investigated for biomedical use. Superparamagnetic nanoparticles (SPIONs) of magnetite (Fe3O4) and maghemite (γ-Fe2O3) have attracted significant attention due to their biocompatibility and good magnetic properties, which implies their sensibility to applied external magnetic fields. They can be applied in multifunctional approaches by encapsulation of the particles with a suitable coating substance for controlled drug delivery of therapeutic agents in in vivo applications. Other applications are found in the area of magnetic resonance imaging, tissue repair, immune analysis, biological fluids detoxification, magnetic hyperthermia and cell separation. A simple and cost-effective method was developed to obtain Folic Acid (FA) - conjugated Magnetic Nanoparticles (MNs). Colloidal suspensions composed of a single domain of superparamagnetic iron oxide nanoparticles (SPIONs) dispersed in a liquid carrier (distilled water) were synthesized by in-situ co-precipitation and ultrasonication (sonolysis) in a vacuum environment (0.98 Mpa). Before conjugation obtained MNs were processed by electrohydraulic discharges (see Fig. 1.) in two modes: the high discharge current (HC) (several tens of Amperes) and low discharge current (LC) (several Amperes) mode in an aqueous system using a pulsed direct current (PDC). The processing was performed in a low-pressure reactor at high voltage (1-1.5 kV). HC and LC mode regulated by the distance between discharge rods (from 1.5 to 3 mm). The X-ray Powder Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS), Ultraviolet-Visible Spectroscopy (UV-VIS), Vibrating Sample Magnetometry (VSM), Small Angle X-Ray Scattering (SAXS) and Small Angle Neutron Scattering (SANS) were used to characterize obtained samples.

https://nap.sumdu.edu.ua/index.php/nap/nap2019/rt/metadata/3145/0
5th International Conference “Nanotechnologies Nano – 2018Tbilisi, Georgia201819 – 22 NovemberGeorgian Technical UniversityProspectives of high voltage pulsed arc discharge on nanomaterial synthesis and processingposter

Iron oxide nanoparticles (IONPs) are of great interest for researchers working in different fields of physics, chemistry, biology, and medicine. Growing interest is based on their physical-chemical and pharmacokinetic properties. A well-known method of synthesis of IONPs is chemical co-precipitation. Although this method is distinguished by its simplicity, cheapness, and the possibility of producing in a largescale, its main drawback is that it is impossible to uniformly distribute the concentrations of reactants, and control the nucleation and crystal growth. Small-angle neutron scattering (SANS) and small-angle X-ray scattering (SAXS) were used for the determination of the microscale or nanoscale structure of particle systems in terms of average particle sizes, shapes, size distribution, and surface-to-volume ratio. Additional information was obtained on the colloidal stability, the quality of the dispersion, and the amount and character of the possible particle aggregation. We used Dynamic light scattering (DLS) technique to determine the size distribution profile of small particles in suspension in order to calculate hydrodynamic radius of aspheres. For assessment of stability of colloidal dispersions, we measure the zeta potential of the samples. The magnitude of the zeta potential indicates the degree of electrostatic repulsion between adjacent, similarly charged particles in a dispersion. The proposed approach, as shown by preliminary studies, significantly improves the dispersion of the solution. Strong oscillations associated with the electrohydraulic effect, additionally disperse the chemically synthesized particles. In the present work, we overview trends of the technique of nanomaterial production and processing by pulsed high voltage discharge in solution/water. This work is supported by National Shota Rustaveli National Science Foundation (Grants # # PhDF2016–59 and Ys17–15) and by Central European Research Infrastructure Consortium (Elettra – Proposal No: 20177016). We are grateful to V. Gabunia and E. Sanaia from the I. Vekua Sokhumi Institute of Physics & Technology for their assistance in part of measurements of physical parameters.

https://dspace.nplg.gov.ge/handle/1234/312052
PHYSICS 17 / International Conference on Physics and Natural Sciences Istanbul, Turkey2017February 17-18DAKAM Polyvinyl alcohol (pva) coated magnetic nanoparticles for biomedical applicationposter

Iron oxide nanoparticles containing in magnetic fluids are used in a rapidly expanding number of research and practical applications in the biomedical field magnetic resonance imaging (MRI) contrast enhancements, direct drug delivery systems, hyperthermia treatment as well as labelling and separation of biological materials. In the last decade, increased investigations with several types of iron oxides have been carried out in the field of magnetic NPs, among which magnetite (Fe3O4) and maghemite is the very promising and popular candidates since their good biocompatibility. The main technological challenges are related to the improvement of the following properties: precise control of size, shape, stability, and dispersibility of NPs in desired solvents.

This review is focused on the synthesis of superparamagnetic iron oxide nanoparticles (SPIONs). Iron oxide nanoparticles coated with PVA4–88 was synthesized by two methods: In the first case, iron oxide nanoparticles coating with PVA4–88 is carried out after the synthesis of the magnetic nanoparticles, and in the second case - in the synthesis process. In both cases the Iron oxide nanoparticles were synthesized by suitable modification of the standard synthetic procedure with a controlled co-precipitation technique in one-pot in a vacuum environment. A Co-precipitation technique under vacuum environment was used to prevent undesirable critical oxidation of Fe2+. The obtained PVA coated biocompatible 10-20 nm sized nanoparticle dispersive solution with pH ≈ 7.4 and solid phase content ranging from 0.02-1 % w/v. Prepared iron oxide nanoparticles were characterized using X-ray diffraction (XRD). Particles sizes measured from TEM are approximately 10–20 nm, the magnetic cores exhibit somewhat irregular shapes varying from spherical, oval, to cubic. Also has been investigated magnetic properties. The Vibrating Sample Magnetometer (VSM) studies indicates the presence of superparamagnetic nanoparticles in a magnetic ferrofluid and surfactant influence on the characteristic of the magnetization at room temperatures into high and low magnetic fields. 

This work was supported by Shota Rustaveli National Science Foundation (Grant No. PhDF2016_59)

https://sin.put.poznan.pl/publications/details/i14659
22nd International Conference and Expo on Nanoscience and Molecular NanotechnologyFrankfurt, Germany20176-8 NovemberConference SeriesElectrohydraulical synthesis of magnetite nanoparticles for biological applicationposter

We propose electrohydraulic discharges assisted chemical co-precipitation technique in order to develop a simple, cost-effective, large-scale manufacturing of bio-applicable iron oxide nanoparticles involving plasma arc discharges in base solution. By this method, as preliminary experiments shows, we obtain better dispersing the formed nanoparticles at the initial stage, process their surface (static stabilization, H and OH radical addition for better absorbance) by pulsed discharges and add to the fluid the bactericidal properties. After that, the covering (stabilizing) of the monodisperse nanoparticles with surfactant is relatively easy to follow, with bioactive molecules (dextran, polyvinyl alcohol, polyethylene glycol, etc.), followed by washing from chemical reaction residuals, additional ultrasound homogenization and centrifugation.

Transition electron microscopy, vibrating sample magnetometer, VIS spectrophotometry and bactericidal research was used to characterize obtaining samples. 


https://books.google.ge/books?id=42NnDwAAQBAJ&pg=PA40&lpg=PA40&dq=Proceedings+of+22nd+International+Conference+and+Expo+on+Nanoscience+and&source=bl&ots=HTBdqGRDBX&sig=ACfU3U1dEhBlUSJJug0vN0vfs2aY9qFDOQ&hl=ka&sa=X&ved=2ahUKEwj6xMmG2cr3AhUCSfEDHWCjCloQ6AF6BAgPEAM#v=onepage&q=Proceedings%20of%2022nd%20International%20Conference%20and%20Expo%20on%20Nanoscience%20and&f=false
17 International Multidisciplinary Scientific GeoConference SGEM 2017Albena, Bulgaria201727 June - 06 JulySGEMChemical Co-Precipitation Synthesis and Characterization of Polyethylene Glycol Coated Iron Oxide Nanoparticles for Biomedical Applicationsposter

Surface modified superparamagnetic iron oxide nanoparticles (SPIONs) are a kind of novel functional materials, which have been widely used in the various areas. The main requirements to magnetic nanoparticles for biomedical applications are the nontoxicity, biocompatibility and high-level accumulation in the target tissue or organ, chemical stability, simplicity and reproducibility of synthesis. The composition and characteristics of the SPION surface have a strong influence on their stability, distribution, and biocompatibility, with regard to cellular uptake and cytotoxicity. This study is focused on the development of the synthesis of aqueous suspensions of SPIONs stabilized with hydrophilic polymer - polyethylene glycol (PEG). Iron oxide nanoparticles were synthesized via a controlled co-precipitation technique in the vacuum environment. Crystalline structures and particle sizes obtained iron oxide nanoparticles were characterized using X-ray diffraction (XRD) and Transmission Electron Microscopy (TEM). Magnetic properties were studied using the Vibrating Sample Magnetometer (VSM). Also, investigated the influence of PEG-coated SPIONs on the viability of the bacterial colonies of the Staphylococcus epidermidis. The detected bactericidal effect was time and growth phase-dependent. The outcomes of this study will further lead to the possible application of SPIONs for human chronic wound healing.

https://www.flickr.com/photos/sgem_geoconference_2017/
SPIE 10019, Optoelectronic Devices and Integration VIBeijing, China 201612-14 ოქტომბერიSPIESolar cells based on InP/GaP/Si structureposter

Solar cells (SCs) based on III-V semiconductors are reviewed. Presented work emphases on the Solar Cells containing Quantum Dots (QDs) for next-generation photovoltaics. In this work the method of fabrication of InP QDs on III-V semiconductors is investigated. The original method of electrochemical deposition of metals: indium (In), gallium (Ga) and of alloys (InGa) on the surface of gallium phosphide (GaP), and mechanism of formation of InP QDs on GaP surface is presented. The possibilities of application of InP/GaP/Si structure as SC are discussed, and the challenges arising is also considered.

https://spie.org/conferences-and-exhibitions/past-conferences-and-exhibitions/photonics-asia-2016?SSO=1
4th International Conference “Nanotechnologies” Nano –2016 Tbilisi, Georgia2016October 24 -27Georgian Technical UniversityThe role of Fe3O4 nanoparticles on superconductivity of MgB2poster

We consider the effect of nano Fe3O4 doping on the superconducting properties of MgB2. To do this, we for the first time turn on the electrohydraulic effect (Yutkin effect) [4] in a well-known scheme for the treatment (synthesis) of nanoparticles in order to significantly reduce departure from average size of particles and for ensuring the reproducibility of the synthesis process of the composite MgB2- Fe3O4.

Nano- Fe3O4 (of various sizes) doped polycrystalline MgB2 samples were synthesized by encapsulation of well mixed high quality Mg, B and nano- Fe3O4 powders. In order to study the effect of magnetic particles on superconductivity, the composites of (MgB2)0.98(Fe3O4)0.02 was synthesized with former sintered at different temperatures. The superconducting properties were investigated in the case of samples sintering at high temperature (7500C) and at low temperature (3500C).

We have investigated the effect of the addition of several concentrations of magnetite Fe3O4 nanoparticles on the microstructure, critical temperature Tc and the critical current density Jc in the composite MgB2-Fe3O4 material. The study was conducted using X-ray Diffraction (XRD), Energy Dispersive X-Ray Spectroscopy (EDS) and Vibrating sample magnetometer (VSM) for the magnetization measurements. 

https://dspace.nplg.gov.ge/handle/1234/233437
11th International Conference and Expo on Nanoscience and Molecular NanotechnologyRome, Italy2016October 20-22Conference SeriesMagnetic and optical properties of PEG and dextran coated magnetic nanoparticlesposter

The development of the synthesis of stable aqueous suspensions of superparamagnetic iron oxide nanoparticles stabilized with unmodified polyethylene glycol (PEG) at two molecular weights (4000 and 6000 Da) and dextran-40 has been reported. The obtained biocompatible polymer (PEG)m and dextran coated nanoparticle dispersive solution with pH �?? 6.5 and solid phase content ranging from 0.02-0.75 % w/v has been investigated for optical and magnetic properties. Biomedical application requires the biocompatible superparamagnetic iron oxide nanoparticles (SPION), which are stable and well dispersed in water at physiological pH or in physiological salinity. Biocompatible 10-20 nm sized SPIONs have been synthesized via co-precipitation method in the vacuum environment. These SPIONs have been modified with PEG and dextran in one-pot synthesis. Vibrating Sample Magnetometer (VSM) studies show the effect of phase transformations on the magnetic properties of the nanoparticles and surfactant influence on the characteristic of the magnetization at room temperatures into high and low magnetic fields.

https://www.walshmedicalmedia.com/proceedings/magnetic-and-optical-properties-of-peg-and-dextran-coated-magnetic-nanoparticles-35133.html
1st International Conference on Applied Chemistry (ICAC-1), Hurghada, Egypt2016March 14-17ICAC-1Some physical parameters of PEG-modified magnetite nanofluidsposter

The development of the synthesis of stable aqueous suspensions of

superparamagnetic iron oxide nanoparticles stabilized withunmodified polyethylene glycol

(PEG) at two molecular weights (4000 and 6000 Da) and several PEG/iron ratios has

been reported. The obtained biocompatible polymer (polyethylene glycol -PEG) coated

nanoparticle dispersive solution with pH ≈ 6.5 and solid phase content ranging from

0.02-0.75 % w/v has been investigated for optical and magnetic properties. Biomedical

application requires the biocompatible superparamagnetic iron oxide nanoparticles (SPION), which are stable and well dispersed in water at physiological pH or in physiological salinity. Biocompatible 10-20 nm sized SPIONs have been synthesized via co-precipitation method in the vacuum environment. These SPIONs have been modified with PEG in one-pot synthesis. Vibrating Sample Magnetometer (VSM) studies show the effect of phase transformations on the magnetic properties of the nanoparticles and surfactant influence on the characteristic of the magnetization at room temperatures into high and low magnetic fields.

3rd International Conference “Nanotechnologies” Nano – 2014. Tbilisi, Georgia2014October 20 – 24Georgian Technical UniversityNew Method of Preparation of Superparamagnetic Nanoparticlesposter

Magnetic nanoparticles have shown great potential in many biological and biomedical applications such as targeted drug delivery, magnetic fluid hyperthermia, magnetic resonance imaging, and tissue engineering. All these applications require magnetic nanoparticles to be water-soluble and biocompatible. For biological and biomedical applications, magnetic iron oxide nanoparticles are the primary choice because of their biocompatibility and chemical stability. The co‐precipitation method is the most effective technique for preparing aqueous dispersions of iron oxide nanoparticles because the synthesis is conducted in water. For this report, we studied several biological molecules as surface coatings to achieve biocompatibility such as ascorbic acid, polyvinyl alcohol, poly(ethylene glycol) (PEG), and dextran. These molecules were used to control the particle size, prevent the nanoparticles from aggregating, and achieve biocompatibility. The most conventional method for obtaining Fe3O4 is by co-precipitation. The size and shape of the iron oxide NPs depend on the type of salt used (such as chlorides, sulfates, nitrates, perchlorates, etc.), the ferric and ferrous ions ratio, the reaction temperature, the pH value, ionic strength of the media, and the other reaction parameters (e.g. stirring rate, dropping speed of basic solution). But this method needs to be improved in order to raise the monodispersity that is necessary in the case of biomedical applications. To do this, we for the first time turn on the electrohydraulic effect in a well-known scheme for the treatment of nanoparticles in order to significantly reduce the scatter radius of particles. To do this, we have a device created by us that is stationary pilot equipment. As a result, the size radius of particles becomes almost the same, and the particle solubility in water is increased. We carried out the preparation of the magnetic colloid by an adapted co-precipitation method in the presence of an electrohydraulic effect, with further magnetite stabilization. The samples are analyzed by VSM at room temperature to find the saturation magnetization of ascorbic acid-coated iron oxide NPs.

https://dspace.nplg.gov.ge/handle/1234/141860
2nd International Conference ""Nanotechnologies"" Nano - 2012Tbilisi, Georgia201219 – 21 სექტემბერიGeorgian Technical University"Use of electrohydraulic effect medical To obtain high-dispersion magnetic nanofluid for the intended purpose"poster

When obtaining a magnetic fluid for medical use, which is a colloidal dispersion with a volume fraction of 25%, it is necessary to solve several tasks: It is necessary to obtain small (10-19 nm) magnetic particles and it is also necessary to cover the dispersed phase particles with a molecular layer of stabilizer, which should prevent the particles from interacting and ensure a stable colloidal system of single-domain magnetic particles dispersed in the liquid carrier. Today's dispersion methods, such as ultrasonic processing and centrifugation, provide a good degree of homogenization, which manifests itself in the separation of particles stuck in the liquid, but the large size reduction of some aggregates already formed is a difficult process and requires high energy to destruct their bond. The advantage of electro-hydraulic processing of Fe3O4 nanofluids containing chemically obtained nanoparticles over centrifugation and ultrasonic processing methods is the high degree of homogenization of the nanofluid. The essence of this method is to discharge the liquid in a closed or open vessel with an electric charge with a special impulse, resulting in a high hydraulic pressure around the discharge zone, which performs a useful mechanical work, in our case homogenization.

https://dspace.nplg.gov.ge/handle/1234/141858
Photonics III, Institute of cybernetics ConferenceTbilisi, Georgia201124-25 თებერვალიGeorgian Technical UniversityStructural disorders in GaMnSb films and their impact on the anomalous Hall effectposter

Scientists are now working to create nanoscale multilayer structures consisting of alternating layers of ferromagnetic metal and non-magnetic semiconductors that study the problems of spin injection, manipulation, control, and detection. Great importance is attracted to semiconductors, which are the best spin injectors. To solve these problems, open magnetic semiconductors are selected, in which the ions of magnetic impurities are represented in a certain percentage ratio (eg: 5 at%). Such semiconductor compounds are distinguished by a high degree of spin polarization and a Hall effect at room temperature, which is one of the important preconditions for the practical realization of a spintronic device.

Photonics III, Institute of cybernetics ConferenceTbilisi, Georgia201124-25 თებერვალიGeorgian Technical UniversityObtaining and Investigating Low-Resistance ohmic Contacts on Gallium Arsenide "poster

An ohmic contact is required to switch into any electrical device based on semiconductors. The development of semiconductor nanotechnology allows the creation of active elements several tens of nanometers in size, but the acquisition of ohmic contacts of such dimensions is currently unattainable, so researchers suggest that research into current processes in semiconductor and metal contact will be important for both scientific and practical purposes.

Photonics III, Institute of cybernetics ConferenceTbilisi, Georgia201124-25 თებერვალიGeorgian Technical UniversitySynthesis of magnetic nanofluids for medical appointmentposter

The chemical coprecipitation method for the production of magnetic nanoparticles developed by us with two-step synthesis technology is an obtained method for the production of magnetite (Fe3O4) nanoparticles. It includes the chemical method of obtaining nanoparticles along with the washing procedures, as well as the stabilization / surfactation of nanoparticles, ultrasonic processing, centrifugation, and their placement in the final transfer fluid. This complex method is generally considered to give small sizes of finely dispersed nanoparticles and is distinguished by a relatively high stabilization in the carrier fluid. Added the non-toxicity and biocompatibility of the selected material, is a prerequisite for medical use.

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Scientific editor of a monograph in Georgian


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Review of a scientific professional journal / proceedings


Member of the editorial board of a peer-reviewed scientific or professional journal / proceedings


Participation in a project / grant funded by an international organization


Complex study of spin transfer in discrete alloys Ferromagnetic - Semiconductor With controlled disorder.International Science and Technology Center, ISTC, -G- 1335, Ukraine უკრაინა 01.09.2006 - 01.09.2009researcher
Complex study of the structure and morphology of coated superparamagnetic iron oxide nanoparticles in ferrofluids obtained by new controllable techniqueCentral European Research Infrastructure Consortium (CERIC) - Project #20177016 20.11.2017 / 20.11.2019key personal
Impulse arc discharge Study of the effect of biological effects The use of magnetic nanoparticles On surface modification Central European Research Infrastructure Consortium CERIC Project # 20192124, Europe 30.08.2019 - 30.08.2020Project manager

Participation in a project / grant funded from the state budget


GNSF project # GNSF/ST08/4-426 -Investigation of the Semiconductor Optical Switch Devise.Shota Rustaveli National Science Foundation 01.09.2009 01.09.2010Researcher (Experiment)
Continuous production line for synthesis of modified magnetic nanoparticles # AR/96/3-250/13Shota Rustaveli National Science Foundation 04.04.2014 04.04.2016key personal
Presidential grants for young scientists # PG/54/3-250/1 - Electrohydraulic equipment to determine the effectivness of high despersive magnetite-containing nanofluid of the medical use.Shota Rustaveli National Science Foundation 23.12.2014 23.12.2015project manager
Short-term individual travel state scientific grant, solar elements in the InP / GaP / Si structure, China, Agreement # 03/88Shota Rustaveli National Science Foundation 12.10.2016 14.10.2016Executive
Grant Competition for Mobility and International Scientific Measures, Electrohydraulic Synthesis of Magnetite Nanoparticles of Biological Application, Germany, (Grant Agreement MG_2)Shota Rustaveli National Science Foundation 06.11.2017 08.11.2017Executive
Synthesis of bio applicable magnetic nanofluid using plasma generation in fluid # YS17_15Shota Rustaveli National Scientific Foundation 13.12.2017 13.12.2019Project manager
Evaluation of therapeutic effect of magnetic nanoparticles functionalized with antitumor drug on breast cancer cells.Shota Rustaveli National Scientific Foundation of Georgia, Applied Research Grants Program # CARYS-19-976 - 30.07.2020 /26.10.2021key personal
Applied Research State Grants # AR-19-1211 - Synthesis of the multifunctional magnetic nanosystem with innovative technology for medical applicationSHOTA RUSTAVELI NATIONAL SCIENCE FOUNDATION OF GEORGIA 23.12.2019- 23.12.2022Project coordinator

Patent authorship


AP 2021 15641sakpatenti Shalva Kekutia, Jano Markhulia, Vladimer Mikelashvili, Liana SaneblidzeElectrohydraulic discharge device For homogenization of nanoparticlesIssued

Membership of the Georgian National Academy of Science or Georgian Academy of Agricultural Sciences


Membership of an international professional organization


Membership of the Conference Organizing / Program Committee


International Conference" "Nanotechnologies" Nano, Tbilisi, Georgia 2016-დღემდე

National Award / Sectoral Award, Order, Medal, etc.


Honorary title


Monograph


Handbook


Research articles in high impact factor and local Scientific Journals


Synthesis and in vivo investigation of therapeutic effect of magnetite nanofluids in mouse prostate cancer model. Digest Journal of Nanomaterials and Biostructures, 2018, Vol.13, No.4, p. 1081-1090. Grant Project

Nanofluids containing superparamagnetic iron oxide nanoparticles (SPIONs) stabilized with a biocompatible polymer polyethylene glycol (PEG) of molecular weight 4000 were synthesized by suitable modification of the standard synthetic procedure with a controlled co-precipitation technique in one-pot approach in a vacuum environment. The obtained samples were characterized using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Small-Angle X-ray Scattering (SAXS), Transmission Electron Microscopy (TEM) and Vibrating Sample Magnetometry (VSM). The therapeutic effect of magnetic nanofluids containing bare and PEG-coated magnetite nanoparticles has been studied in either monotherapy or combined therapy with anticancer drug mitoxantrone in mouse prostate cancer model. The therapeutic effect was the strongest in combined use of mitoxantrone with magnetite nanoparticles.

https://www.chalcogen.ro/1081_MarkhuliaJ.pdf
Synthesis ad properties of RGO-Fe3O4 Hybrid nanomaterial and its polimer Composite. Interational Journal of Nanoscience, 2019, Vol 18, Nos. 3&4 1940076 (4 pages)Grant Project

Simple, reliable and scalable tool for the decoration of reduced graphene oxide (RGO) by iron oxide nanoparticles and the creation of polymer–RGO–Fe3O4 thin ¯lms are proposed. The composite is magnetically sensitive. Structural and microscopic studies and resistance measurements were performed. It has been found that these composites possess the hole-type conductivity.

https://doi.org/10.1142/S0219581X19400763
Folic acid conjugation of magnetite nanoparticles using pulsed electrohydraulic discharges. Serb. Chem. Soc., 2021, v 86 (2) 181–194. Grant Project

The sonochemical coprecipitation reaction with moderate ultrasound irradiation in a low vacuum environment was used to obtain aqueous colloidal suspensions of iron oxide nanoparticles (IONPs). The synthesized magnetite nanoparticles were conjugated directly by folic acid using electrohydraulic discharges as a processing technique before modification of the surface of the nanoparticles. Electrohydraulic discharges were applied in two operational modes with high and low power pulsed direct currents between the electrodes. The physical and chemical properties of the obtained samples were studied using X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS). The investigation proved an inverse cubic spinel structure of magnetite with folic acid attachment to the magnetite surface (mean crystallite diameter in the samples, D, ranges 25–31 nm by XRD and SAXS). It was found that the processing with electrohydraulic discharges increased the colloidal stability of the folic acid-magnetite nanoparticle dispersions.

https://doi.org/10.2298/JSC200414053M
Stable aqueous dispersions of bare and double layer functionalized superparamagnetic iron oxide nanoparticles for biomedical applications. Materials Science-Poland, 2021, vol.39, no.3, pp. 331-345. Grant Project

Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted the particular interest of scientists from various disciplines since their obtaining to the present day. The physicochemical and pharmacokinetic properties of SPIONs-containing magnetic nanofluids, and their applicability in biomedicine, largely depend on the stability of the colloidal system, particle size, size distribution, net magnetic moment, phase composition, and type and properties of stabilizers. Also, in some cases, when using magnetic nanoparticles for biomedical purposes, it is necessary that the stabilizing ligands of nanoparticles should not significantly change the magnetic properties. From this point of view, the preparation of stable colloidal systems containing bare iron oxide nanoparticles (BIONs) in water at physiological pH attracts particular attention and becomes increasingly popular in scientific circles. This study is focused on the development of the synthesis of aqueous suspensions of SPIONs stabilized with various organic molecules (oleic acid [OA] and poly(ethylene glycol) monooleate - with molecular weights 460 and 860) using a modified controlled chemical coprecipitation reaction, as well as stable nanofluids containing BIONs in an aqueous medium at neutral pH (near-physiological). The obtained samples were characterized using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy, small-angle x-ray scattering (SAXS), dynamic light scattering (DLS), electrophoretic light scattering (ELS), and Vibrating Sample Magnetometry.

https://sciendo.com/es/article/10.2478/msp-2021-0028. DOI: https://doi.org/10.2478/msp-2021-0028.

Publication in Scientific Conference Proceedings Indexed in Web of Science and Scopus


Chemical Co-Precipitation Synthesis and Characterization of Polyethylene Glycol Coated Iron Oxide Nanoparticles for Biomedical Applications. 17 International Multidisciplinary Scientific GeoConference SGEM 2017. Albena, Bulgaria. Grant Project

Surface modified superparamagnetic iron oxide nanoparticles (SPIONs) are a kind of novel functional materials, which have been widely used in the various areas. The main requirements to magnetic nanoparticles for biomedical applications are the nontoxicity, biocompatibility and high-level accumulation in the target tissue or organ, chemical stability, simplicity and reproducibility of synthesis. The composition and characteristics of the SPION surface have a strong influence on their stability, distribution, and biocompatibility, with regard to cellular uptake and cytotoxicity. This study is focused on the development of the synthesis of aqueous suspensions of SPIONs stabilized with hydrophilic polymer - polyethylene glycol (PEG). Iron oxide nanoparticles were synthesized via a controlled co-precipitation technique in the vacuum environment. Crystalline structures and particle sizes obtained iron oxide nanoparticles were characterized using X-ray diffraction (XRD) and Transmission Electron Microscopy (TEM). Magnetic properties were studied using the Vibrating Sample Magnetometer (VSM). Also, investigated the influence of PEG-coated SPIONs on the viability of the bacterial colonies of the Staphylococcus epidermidis. The detected bactericidal effect was time and growth phase-dependent. The outcomes of this study will further lead to the possible application of SPIONs for human chronic wound healing.

https://www.flickr.com/photos/sgem_geoconference_2017/